After watching this movie, the mood was very complicated. The director used the horror film to show the story of an elderly person with Alzheimer's disease waiting to die. Cruel and realistic, people with Alzheimer's disease will slowly lose their memory, behavioral ability, and cognitive ability, and finally slowly become a soulless body, slowly dying in fear and forgetting. ......
The following is the explanation and cause of Alzheimer's disease, taken from Baidu Encyclopedia:
Cause
The disease may be a group of heterogeneous diseases, which only develops under the influence of a variety of factors (including biological and psychosocial factors). From the current research, there are more than 30 possible factors and hypotheses for the disease, such as family history, female, head trauma, low education level, thyroid disease, mother's childbearing age is too high or too low, virus infection and so on. The following factors are related to the onset of the disease:
1. Family history Most epidemiological studies have suggested that family history is a risk factor for the disease. Some family members of patients with the same disease are higher than the general population. In addition, it is also found that the risk of congenital stupidity is increased. Further genetic studies confirmed that the disease may be caused by an autosomal dominant gene. Recently, through gene mapping studies, it was found that the pathological gene of amyloid in the brain is located on the 21st pair of chromosomes. Obviously, dementia is related to genetics. Congenital stupidity (DS) has similar pathological changes to the disease. The probability of developing the disease in adults is about 100%. The disease-causing gene of DS is known to be located on chromosome 21, which arouses great interest in the genetics of the disease. However, it is difficult to study the genetics of the disease. Most researchers have found that the risk of the disease for family members of patients is about 3 to 4 times higher than that of the general population. St.George-Hyslop et al. (1989) reviewed the family research data of the disease and found that the risk of family members suffering from the disease was 14.4% for parents and 3.8% to 13.9% for siblings. Using life expectancy statistical analysis, the risk rate of FAD first-degree relatives is as high as 50%, while the control group is only 10%. These data support that some early onset FAD is a group of age-related dominant autosomal dominant inheritance; In the literature, there is a family with only female disease. X-linked inheritance can be ruled out because it is very rare, and most sporadic cases may be the result of the interaction of genetic susceptibility and environmental factors. There are at least the following four known genetic academic points related to AD: The early-onset AD locus is located on chromosomes 21, 14, and 1, respectively. The corresponding possible pathogenic genes are APP, S182 and STM-2 genes. The late-onset AD locus is located on chromosome 19, and the possible pathogenic gene is the apolipoprotein E (APOE) gene.
2. Some physical diseases such as thyroid disease , immune system disease, epilepsy, etc., have been studied as risk factors for the disease. People with a history of hypothyroidism have a high relative risk of developing the disease. There are more epileptic seizures before the onset of the disease . A history of migraine or severe headache is not related to the disease. Many studies have found that the history of depression , especially the history of depression in the elderly , is a risk factor for the disease. A recent case-control study found that in addition to depression , other functional mental disorders such as schizophrenia and paranoid psychosis are also related. The chemical substances that have been studied as risk factors for the disease include heavy metal salts, organic solvents, pesticides, and drugs. The role of aluminum has always been a concern because animal experiments have shown that aluminum salts have an impact on learning and memory; epidemiological studies have suggested that the prevalence of dementia is related to the aluminum content in drinking water. It may be that the accumulation of neurotoxins such as aluminum or silicon in the body accelerates the aging process.
3. Head trauma Head trauma refers to head trauma accompanied by disturbance of consciousness . Brain trauma has been reported as a risk factor for the disease. Clinical and epidemiological studies suggest that severe brain injury may be one of the causes of some of the diseases.
4. Others Progressive failure of the immune system, weakening of the body's detoxification function, and lentivirus infection, as well as social and psychological factors such as widowhood, living alone, financial difficulties, and ups and downs in life, can become the triggers for the disease.
Clinical manifestations
The onset of the disease is slow or insidious, and the patient and family members often cannot tell when it started. It is more common in elderly people over 70 years old (73 years old in men and 75 years old in women). A small number of patients have symptoms that quickly become clear after physical diseases, fractures or mental stimulation. There are more women than men (3:1 for women: men). Mainly manifested as the decline of cognitive function, mental symptoms and behavioral disorders, and the gradual decline in the ability of daily living. According to the degree of deterioration of cognitive ability and physical function, it is divided into three periods.
The first stage (1 to 3 years) is the mild dementia period. It is manifested as memory loss, prominent forgetting of recent events; decreased judgment ability, patients cannot analyze, think, and judge events, and are difficult to deal with complex issues; work or housework animation is inattentive, unable to independently carry out shopping, economic affairs, etc., social difficulties; Although still able to do some familiar daily tasks, he is at a loss and incomprehensible to new things, emotionally indifferent, occasionally agitated, and often suspicious; there is time disorientation, and he can be oriented towards the place and the person. , Difficulty in orientation to geographic location, poor visual and spatial ability of complex structure; Few language vocabulary and difficulty in naming.
The second stage (2-10 years) is the period of moderate dementia . It is manifested as severely impaired far and near memory, decreased visual and spatial ability of simple structure, disorientation in time and place; severely impaired in dealing with problems and distinguishing similarities and differences of things; unable to independently perform outdoor activities, in dressing, personal maintaining personal hygiene and instrumentation needs help; can not be calculated; the emergence of various neurological disorders like, visible aphasia, apraxia and agnosia; feelings of apathy becomes edgy, often kept walking, visible urinary incontinence .
The third stage (8-12 years) is the period of severe dementia . The patient has completely relied on the caregiver, severe memory loss, and only a fragment of memory; unable to take care of himself in daily life, incontinence of urine and feces, showing silence, limb stiffness, physical examination showed positive pyramidal tract signs, with strong grip, groping and sucking and other primitives reflection. Eventually coma, usually died of complications such as infection.
According to the above analysis, the following inferences are obtained, and the analysis of the movie is started:
1. Edna's behavior in the movie has already hinted to the audience that she is a patient with Alzheimer's disease and the disease has reached at least the second half of the second stage. She has begun to feel fear and despair, and dark green mold appears on her body. Madara implies that the disease is slowly devouring her.
2. Because Alzheimer's disease is hereditary, some of the characteristics have been shown in her daughter Kay. Granddaughter Sam also hinted that she also has this disease, which is very consistent with the genetic mechanism of Alzheimer's disease.
3. The mildew stains on the house suggest that the patient's body is gradually decomposing from the inside, and the pain is abnormal.
4. The glass pattern on the door implies the inheritance of the disease. It turned out that the door was the door of Edna's father's house. After her father died, the door was left as a memorial, indicating that the father passed the inheritance of the disease to his daughter.
5. The endless labyrinth implies that people suffering from diseases start to lose their memories, have confusion in their thinking, and fear that they will forget the one they love, all the good memories, their names, the appearance of their lover, and the endless labyrinth Died in fear. It is mentioned many times in the film that this house is Edna's only memory, some for his father, some for her husband, and some for her daughter and granddaughter. There is a scene in the movie that I remember very deeply. Edna went to the deep forest with the album alone and devoured the photos. It may seem terrifying to outsiders, but in my opinion, this scene touched me deeply. , In order to preserve the good memories, I would not hesitate to eat the photos, because this is the only hope of an old man at dusk, and it is also one of the few things this old man can do.
After sorting out the clues, we can find that this story is a family ethics film under the guise of a horror film. The daughter is unwilling to take care of the sick mother, but when the mother is dying, she finally understands that this is her own responsibility. Ignore this responsibility. As Sam said, “When we were young, they changed diapers for us. Now that they are old, shouldn’t we change diapers for them?” In the end, the three grandparents lay on the bed, also implying that Key is getting old. Sam will love her and take care of her. It also implies that this disease will be passed on to Sam, and her mother already has a green mold...
According to a report issued by the International Alzheimer's Association, every three seconds, there will be one more Alzheimer's disease patient in the world. By 2050, this number will reach 130 million. Patients with Alzheimer's disease are like an eraser in their minds, erasing the memories of life and the important people in life little by little. At the same time, as their illness worsens, they gradually lose control over themselves, and the uncertainty caused by unclear expressions and difficulties in understanding may make them confused, helpless, irritable, sensitive, and suspicious. For family members, this is also a difficult journey, because there is currently no specific medicine that can cure Alzheimer’s disease. They not only have to take on the heavy nursing work, but also face the inevitable deterioration of the patient’s condition, and one day they will suffer. The pain of forgetting and even pushing away the loved ones. When we face Alzheimer's patients, we are about forgetting, pushing away, and making a lot of noise. We still have to give love and energy, do our best to take care of our loved ones, and walk the last part of our life with dignity.
Just like the note "I Am Love" that flashed by in the film...
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