- Screenwriter Sean Salerno bought the copyright of Robert Graysmith’s novel "Zodiac" when he was 19 years old, and the two of them worked with Graysmith on the story for many years, and then sold the script to I won a seven-figure author's remuneration for Touchstone Pictures, a subsidiary of Disney. Although the screenwriter of the film did not include Sean Salerno, he did write multiple versions of the script for the story of the true San Francisco series of murderers.
- The parents of Anthony Baignier, who is also an actor and producer, are classmates of a victim who died at the hands of the "Zodiac" in San Francisco.
- In the film, the role of Linda Flynn was originally played by Bijou Phillips, but because she had to be re-shooted later, and Philip’s schedule could not be adjusted, so she had to be replaced by Kerry Du Val makes a remake.
- Director David Fincher originally asked Gary Oldman to play the role of detective Dave Toscher, but because Oldman will continue to play Sirius in "Harry Potter and the Order of the Phoenix" , So I can only reluctantly give up "Zodiac".
- David Fincher's strict requirements for performance made Jack Gyllenhaal, one of the leading actors, suffer. On the first day of filming, the first scene was NG 67 times.
Zodiac behind the scenes gags
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[after the shooting of Darlene Ferrin and Mike Mageau]
Police Officer: [over the phone] Vallejo Police Department.
Zodiac 1 & 2: I wanna report a murder. No... a double murder.
Police Officer: May I have your name and...?
Zodiac 1 & 2: [interrupting] If you go one mile east on Columbus Parkway, to a public park, you'll find kids in a brown car. They were shot with a 9mm Luger. I also killed those kids last year
[referring to David Faraday and Betty Lou Jensen]
Zodiac 1 & 2: ... Good... bye...
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Melvin Belli: Inspectors, he sent this letter directly to my residence. It is a cry for help intended as a private communique.
Dave Toschi: Which is why you contacted The Chronicle.
Melvin Belli: The people have a right to know. Toddy?