The story takes place in a small town in Louisiana-Bon Temp. Because the Japanese invented a kind of artificial synthetic blood called "True Blood", vampires can obtain blood by purchasing to make a living. They transformed from a legendary monster into an ordinary citizen overnight. Although human beings are no longer a dish for vampires, in theory the two can live together peacefully, but the understanding of these "out of the coffin" creatures still needs to be strengthened. Religious leaders and government officials chose their positions, but in the small town of Bon Temp, the trial has not yet begun.
Sookie Stackhouse (played by Anna Paquin) is a mind-reading barmaid who knows how it feels to be expelled from society. Since vampires don't have brain waves for her to peek, she is happy to deal with them, especially the handsome 173-year-old Bill Comton (played by Stephen Moyer). But when Sookie is involved in a series of mysterious events following Bill's arrival, tolerance will be forced to be tested.
When the vampire walks out of the coffin, walks out of the crevice of existence that opposes human beings, walks out of the curse of loneliness at the top of the biological chain, will our world still be the original world?
