On the day of its premiere on September 12, 2010, it achieved a box office opening, winning 10.8 million U.S. dollars, topping the list. In the three days of the weekend, a total of 27.7 million US dollars were collected at the box office, winning the box office championship this weekend with an absolute advantage. This achievement surpassed the premiere of "Resident Evil 3: Extinction" and created the best opening record of the series, in which 3D cinema became the main source of income.
On September 10, 2010, the first weekend of landing on the Taipei Film City received an excess box office of 45.59 million, which set a record high for the series of films in Taipei.
"Resident Evil 4: The Afterlife" ranked first among movies released in 2010 with a box office of 418 million yen in two days in Japan.
Since the official release of "Resident Evil: Reborn" on November 16, 2010, it has continued to maintain its strong momentum at the Chinese box office. As of December 1, 2010, the box office revenue of this movie has exceeded 111 million yuan.
