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The film was originally named "Master Mind", but because this name has been used in tabletop games and TV shows in the 1970s and the copyright of the film name has been registered, it has been changed to "Oobermind".
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Both Ben Stiller and Robert Downey Jr. were interested in the dubbing of the Megamind character of the film, but due to schedule conflicts, they did not appear in the end.
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The blue skin of the protagonist of the villain in the film is a tribute to the superhero spoof "Freakazoid" produced by Stephen Spielberg in 1995.
Megamind behind the scenes gags
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[Minion discovers Bernard in the washing machine]
Minion: [calling] Sir, you really need to clean out your pockets more often!
Bernard: This has been the worst day of my entire life!
Minion: Ahahaha, no worries!
[hits Bernard with the forget-me stick]
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Megamind: [in prison] Good morning, Warden! Great news: I'm a changed man, and I'm ready to reenter society and consolidate!
Warden: You're a villain, and you'll always be a villain! You'll never change! And you'll never leave.
Megamind: You're fun.