- There are 25 locations for the film, including France, Norway, the Czech Republic and all parts of North America have become battlefields. There are the most well-known landmarks in Paris, and the old streets of the Czech Republic serve as French cities for high-speed chasing scenes in the film. In addition, the cold Norway serves as the arctic scene in the film.
- Originally, the Duke's role planned for Sam Worthington to star, but because of the conflict between the filming of "Special Forces" and "Avatar", Sam Worthington finally turned down the "Special Forces" film.
- Dennis Quaid finished filming all of his scenes in the first two months after filming started.
- In preparation for the role of the baroness, Sienna Miller spent four months on physical training, gaining 5 pounds of muscle, and also learned to shoot live ammunition.
- Channing Tatum originally didn't want to star in this movie because he thought such a movie was glorifying the war. After he watched the script of the film, he thought the film was more like a sci-fi action film so he took the film.
G.I. Joe: The Rise of Cobra behind the scenes gags
G.I. Joe: The Rise of Cobra quotes
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The Doctor: So far we've created 20 Neo-Vipers. Nineteen stand before you.
Destro: Is it working?
The Doctor: We injected 1,000 cc of the nanomite solution into each subject. When they finally stopped screaming, brain scans showed a complete inactivity of the self-preservation region of the cortex.
Destro: English, Doctor?
The Doctor: They feel no fear. Cortical nerve clusters showed complete inactivity. They feel no pain. Concepts of morality are disengaged. They feel no regrets. No remorse.
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Destro: Are they completely obedient?
The Doctor: Of course. The real world applications are endless. So, you tell me, is it working?
Destro: Send a team to rendezvous with Storm Shadow and the Baroness.
The Doctor: Consider it done. The Joes will never know what hit them.