Wade Wilson and his girlfriend Vanessa fell in love, but found out that he had cancer. At this time, he met a mysterious man and invited him to join a government organization that can cure his disease. Without Vanessa’s knowledge, Wilson agreed, but he discovered that instead of working for a government organization, he was kidnapped by an unknown organization to test mutant genes. Wilson Qaeda leader Ajax (), and his female assistant Angel Dust () tortured for several years, until his mutant ability to finally mature. Wilson gained the ability to regenerate, just like Wolverine, the cancer was also cured, but in the process, his face and body were disfigured and mentally abnormal.
Wilson evolved into a mercenary named "Deadpool" and pursued and retaliated against Ajax. Then X-Men steel Guinness and his disciples warhead ( )
appear, because they could not understand Deadpool practices and intervene, resulting in Ajax escaped. On the other hand, Deadpool worried that Vanessa would no longer love him because of the change in his appearance, so he didn't tell Vanessa that he was still alive. But when Ajax and Sand Angel kidnapped Vanessa, Deadpool asked the X-Men for help, to rescue his lover and kill the person who caused him to deform.
