- Due to the limited cost, the filming cycle of the film had to be compressed within a short period of 25 days, and the crew was very short on time, funds and equipment.
- Hilary Swank had planned to play the role of Jennifer Garner, but withdrew because of schedule conflicts.
- In the mid-90s, Dennis Hope had planned to put this story on the screen, and Woody Harrison played Woodruff, but no one invested him.
- Brad Pitt and director Mark Foster also planned to make this film. Another interesting combination is Ryan Gosling and director Craig Gillespe.
- "Bad Education" actor Gail García Bernal was expected to play the role of transgender in this film.
- Leto also maintained the shape of the characters in the film between shooting. When he walked into a supermarket wearing a women's clothing, he turned his head back extremely high.
Dallas Buyers Club behind the scenes gags
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Ron Woodroof: I still got HIV?
Dr. Vass: You will always test positive for HIV. And now you've got AIDS for all the toxic shit you've put in your body. You've shut your immune system and now you've got chronic leumonia, among other things. It could cause memory loss, mood swings, aching joints.
Ron Woodroof: So if it sucks, I got it.
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Ron Woodroof: Do you ever miss your regular life?
Dr. Eve Saks: Regular life? What is that? It doesn't exist.
Ron Woodroof: Yeah, I guess. No, I know, I just... I just wanna...
Dr. Eve Saks: What?
Ron Woodroof: Ice-cold beer, a little riding in. Well, take my woman dancing. You know? I want kids. I mean, I got one... one life, right? Mine. But sh... Fuck, I want somebody else's sometimes. Sometimes I just feel like I'm fighting for a life I just ain't got time to live. I want it to mean something.
Dr. Eve Saks: It does.