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The filming took 94 days.
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The crew initially hoped to film scenes of human and elephant fighting in India, but the elephants in India lacked good training, so they had to switch to Thailand.
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Colin Farrell broke his arm and injured his ankle during filming.
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Val Kilmer gained 50 pounds for the film, and it took 1 hour to put on makeup every day.
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Brad Pitt was the original candidate to play, but he refused because of concerns about the role.
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The first person to play Philip was Sean Connery.
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Heath Ledger was also considered to play Alexander the Great.
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The accent of the Macedonian soldiers in the film does not match that of the Greeks, because historically these Macedonians came from remote hill tribes, so they have a Celtic accent in the film, which is of course similar to that of Aristotle and other fine Greeks. People's British accents are very different, but many people don't understand that this is a deliberate design.
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In the Battle of Gaugamela, the Persian army wore black uniforms, but in fact it should be yellow and light purple.
Alexander behind the scenes gags
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[the first time the army has come across monkeys]
Hephaistion: They're animals. Monkeys.
Alexander: Monkey... look at his hands!
Hephaistion: So much like ours.
Alexander: [to the monkey] Hello little man.
[to Hephaistion]
Alexander: Do they speak?
Hephaistion: No. But they do sing, and make noises from the roofs of forests.
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Old Ptolemy: Within hours we were fighting like Jackals for his corpse. The wars of the world had begun. Forty years, off and on, they endured, until we divided his empire in four parts. I think Alexander would have been disappointed in us.